Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R3LQ
|
|||
| Former ID |
DCL001181
|
|||
| Drug Name |
EXC 001
|
|||
| Drug Type |
Antisense drug
|
|||
| Indication | Fibrosis [ICD-11: GA14-GC01; ICD-10: L90.5; ICD-9: 709.2] | Phase 2 | [1] | |
| Company |
ISIS Pharm; Excaliard
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CTGF messenger RNA (CTGF mRNA) | Target Info | . | [1] |
| KEGG Pathway | Hippo signaling pathway | |||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathway Interaction Database | amb2 Integrin signaling | |||
| TGF-beta receptor signaling | ||||
| Reactome | PPARA activates gene expression | |||
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | ||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
| Hair Follicle Development: Induction (Part 1 of 3) | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). | |||
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