Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R2KJ
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| Former ID |
DAP000435
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| Drug Name |
Dicloxacillin
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| Synonyms |
Dichloroxacillin; Diclossacillina; Dicloxaciclin; Dicloxacilin; Dicloxacilina; Dicloxacilline; Dicloxacillinum; Dicloxacycline; Dycill; Dynapen; Maclicine; Methyldichlorophenylisoxazolylpenicillin; Pathocil; Diclossacillina [DCIT]; Dicloxacillin sodium; BRL 1702; Diclocil (TN); Dicloxacilina [INN-Spanish]; Dicloxacilline [INN-French]; Dicloxacillinum [INN-Latin]; R-13423; Dicloxacillin (USAN/INN); Dicloxacillin [USAN:INN:BAN]; Dicloxacillin, Monosodium Salt, Mono-Hydrate; (2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-[[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolylpenicillin; 6-(3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; 6-(3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid; 6beta-{[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carboxamido}-2,2-dimethylpenam-3alpha-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1] | |
| Therapeutic Class |
Antibiotics
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| Company |
Sandoz Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H17Cl2N3O5S
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| Canonical SMILES |
CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
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| InChI |
1S/C19H17Cl2N3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1
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| InChIKey |
YFAGHNZHGGCZAX-JKIFEVAISA-N
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| CAS Number |
CAS 3116-76-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9165, 7849407, 7979067, 8163742, 11335833, 11361072, 11363826, 11366388, 11368950, 11371491, 11374192, 11377112, 11462044, 11466478, 11467598, 11484777, 11486175, 11488797, 11490202, 11492322, 11494746, 14960168, 29286044, 46508182, 47216776, 47440256, 47736481, 47810752, 47810753, 48259229, 48334496, 48415884, 50064670, 50783422, 57304808, 57330050, 85788067, 103234555, 104133803, 104344973, 117541882, 124766323, 134222806, 134337731, 134981835, 135912430, 136357162, 137003736, 140093221, 142567322
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| ChEBI ID |
CHEBI:4511
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| ADReCS Drug ID | BADD_D00657 ; BADD_D00658 | |||
| SuperDrug ATC ID |
J01CF01
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| SuperDrug CAS ID |
cas=003116765
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 2.45E-05). | |||
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Studied Microbe: Bacteroides ovatus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 6.50E-04). | |||
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Studied Microbe: Bacteroides uniformis
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 6.45E-07). | |||
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Studied Microbe: Bacteroides vulgatus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 1.99E-06). | |||
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Studied Microbe: Bacteroides xylanisolvens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides xylanisolvens was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 3.77E-04). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Parabacteroides merdae
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 8.58E-06). | |||
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Studied Microbe: Prevotella copri
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 6.27E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bifidobacterium longum
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium longum was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 2.73E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 9.63E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 1.79E-06). | |||
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Studied Microbe: Clostridium perfringens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 5.52E-07). | |||
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Studied Microbe: Coprococcus comes
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Dorea formicigenerans
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Enterocloster bolteae
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 3.26E-05). | |||
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Studied Microbe: Eubacterium eligens
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 1.99E-05). | |||
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Studied Microbe: Eubacterium rectale
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 2.72E-04). | |||
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Studied Microbe: Lacrimispora saccharolytica
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Roseburia hominis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 2.29E-05). | |||
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Studied Microbe: Roseburia intestinalis
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 1.76E-04). | |||
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Studied Microbe: Ruminococcus bromii
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 1.31E-05). | |||
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Studied Microbe: Ruminococcus gnavus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 1.77E-05). | |||
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Studied Microbe: Ruminococcus torques
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 6.45E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus paracasei
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lactobacillus paracasei was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Streptococcus parasanguinis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Streptococcus salivarius
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 1.67E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Akkermansia muciniphila was decreased by Dicloxacillin sodium salt hydrate (adjusted p-values: 8.08E-07). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Penicillin binding protein (Bact PBP) | Target Info | Binder | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 062286. | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Mechanisms of resistance to beta-lactam antibiotics in Staphylococcus aureus. Scand J Infect Dis Suppl. 1984;42:64-71. | |||
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