Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0QX6B
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| Former ID |
DNC003227
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| Drug Name |
GERANYLGERANYL DIPHOSPHATE
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| Synonyms |
Geranylgeranyl pyrophosphate; Geranylgeranyl diphosphate; GGDP; 6699-20-3; geranylgeranyl-PP; GGPP; UNII-N21T0D88LX; (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate; N21T0D88LX; Geranylgeraniol diphosphate; CHEBI:48861; all-trans-Geranylgeranyl pyrophosphate; all-trans-Geranylgeranyl diphosphate; Diphosphoric acid, mono(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl) ester, (E,E,E)-; Geranylgeranyl pyrophosphate ammonium salt; 2-trans,6-trans,10-trans-geranylgeranyl diphosphate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H36O7P2
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| Canonical SMILES |
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C
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| InChI |
1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+
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| InChIKey |
OINNEUNVOZHBOX-QIRCYJPOSA-N
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| CAS Number |
CAS 6699-20-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3646, 828136, 841770, 7887977, 10300028, 14759890, 24895243, 36889476, 49658594, 49658615, 53789488, 57404798, 57654751, 57654759, 74382378, 76069476, 104245696, 104637770, 126525092, 135071215, 135651491, 137240195, 162221867, 164810599, 177749493, 179292976, 184581503, 188377314, 188377318, 188377322, 188377326, 223733334, 226519596, 226519598, 250133585, 252413814
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| ChEBI ID |
CHEBI:48861
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CAAX farnesyltransferase beta (FNTB) | Target Info | Inhibitor | [2] |
| Farnesyl protein transferase (Ftase) | Target Info | Inhibitor | [2] | |
| Geranyltranstransferase (FDPS) | Target Info | Inhibitor | [2] | |
| BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
| Superpathway of cholesterol biosynthesis | ||||
| Trans, trans-farnesyl diphosphate biosynthesis | ||||
| Geranylgeranyldiphosphate biosynthesis | ||||
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Biosynthesis of antibiotics | ||||
| Metabolic pathways | ||||
| Influenza A | ||||
| HTLV-I infection | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Panther Pathway | Cholesterol biosynthesis | |||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Inactivation, recovery and regulation of the phototransduction cascade | |||
| Cholesterol biosynthesis | ||||
| Activation of gene expression by SREBF (SREBP) | ||||
| WikiPathways | Visual phototransduction | |||
| Activation of Gene Expression by SREBP (SREBF) | ||||
| SREBP signalling | ||||
| Cholesterol Biosynthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3052). | |||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | |||
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