Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0QK5C
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| Former ID |
DIB014106
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| Drug Name |
ALAMIFOVIR
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| Synonyms |
LY-582563; MCC-478; Alamifovir; 2-[2-Amino-6-(4-methoxyphenylsulfanyl)-9H-purin-9-yl]ethoxymethylphosphonic acid bis(2,2,2-trifluoroethyl) diester
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Phase 1/2 | [1] | |
| Company |
Eli Lilly
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| Structure |
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Download2D MOL |
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| Formula |
C19H20F6N5O5PS
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| Canonical SMILES |
COC1=CC=C(C=C1)SC2=NC(=NC3=C2N=CN3CCOCP(=O)(OCC(F)(F)F)OCC(F)(F)F)N
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| InChI |
1S/C19H20F6N5O5PS/c1-32-12-2-4-13(5-3-12)37-16-14-15(28-17(26)29-16)30(10-27-14)6-7-33-11-36(31,34-8-18(20,21)22)35-9-19(23,24)25/h2-5,10H,6-9,11H2,1H3,(H2,26,28,29)
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| InChIKey |
VDBGPMJFHCJMOL-UHFFFAOYSA-N
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| CAS Number |
CAS 193681-12-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatitis B virus Reverse transcriptase priming/DNA synthesis (HBV RTP/DS) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Koinfektion Hepatitis und HIV, Stefan Mauss. Page(75). | |||
| REF 2 | Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine. Correction in: Antimicrob Agents Chemother. 2013 November; 57(11): 5788. | |||
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