Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0QG1B
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| Drug Name |
Aprocitentan
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| Synonyms |
ACT-132577; UNII-MZI81HV01P; 1103522-45-7; Despropyl Macitentan; MZI81HV01P; CHEMBL2165326; CHEBI:76609; Macitentan metabolite; ACT 132577; SCHEMBL3646065; ZINC95553608; BDBM50395672; AKOS028114466; CS-2687; HY-15895; BC600808; 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine; N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]sulfuric diamide
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Phase 2 | [1] | |
| Company |
Idorsia Pharmaceuticals Allschwil, Switzerland Janssen Biotech Horsham, PA
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| Structure |
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Download2D MOL |
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| Formula |
C16H14Br2N6O4S
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| Canonical SMILES |
C1=CC(=CC=C1C2=C(N=CN=C2OCCOC3=NC=C(C=N3)Br)NS(=O)(=O)N)Br
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| InChI |
1S/C16H14Br2N6O4S/c17-11-3-1-10(2-4-11)13-14(24-29(19,25)26)22-9-23-15(13)27-5-6-28-16-20-7-12(18)8-21-16/h1-4,7-9H,5-6H2,(H2,19,25,26)(H,22,23,24)
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| InChIKey |
DKULOVKANLVDEA-UHFFFAOYSA-N
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| CAS Number |
CAS 1103522-45-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:76609
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Endothelin receptor (EDNR) | Target Info | Antagonist | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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