Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0QC5O
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| Drug Name |
Piperazine derivative 6
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| Synonyms |
PMID27724045-Compound-4
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| Drug Type |
Small molecular drug
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| Company |
GSK
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H12ClF5N2O2
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| Canonical SMILES |
C1CN(C(=O)CN1C(=O)C2=C(C(=CC=C2)C(F)(F)F)Cl)C3=C(C=C(C=C3)F)F
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| InChI |
1S/C18H12ClF5N2O2/c19-16-11(2-1-3-12(16)18(22,23)24)17(28)25-6-7-26(15(27)9-25)14-5-4-10(20)8-13(14)21/h1-5,8H,6-7,9H2
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| InChIKey |
VNEYCAAUOFFQMB-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2X purinoceptor 7 (P2RX7) | Target Info | Antagonist | [1] |
| Target's Patent Info | P2X purinoceptor 7 (P2RX7) | Target's Patent Info | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | The NLRP3 inflammasome | |||
| WikiPathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. | |||
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