Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Q0IR
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| Former ID |
DIB018781
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| Drug Name |
AGN193109
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| Synonyms |
AGN 193109; AGN-93109
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C28H24O2
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| Canonical SMILES |
CC1=CC=C(C=C1)C2=CCC(C3=C2C=C(C=C3)C#CC4=CC=C(C=C4)C(=O)O)(C)C
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| InChI |
1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
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| InChIKey |
NCEQLLNVRRTCKJ-UHFFFAOYSA-N
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| CAS Number |
CAS 171746-21-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Retinoic acid receptor alpha (RARA) | Target Info | Antagonist | [2] |
| Retinoic acid receptor beta (RARB) | Target Info | Antagonist | [2] | |
| Retinoic acid receptor gamma (RARG) | Target Info | Antagonist | [2] | |
| KEGG Pathway | Pathways in cancer | |||
| Small cell lung cancer | ||||
| Non-small cell lung cancer | ||||
| Transcriptional misregulation in cancer | ||||
| Acute myeloid leukemia | ||||
| Pathway Interaction Database | Retinoic acid receptors-mediated signaling | |||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Mesodermal Commitment Pathway | ||||
| Endoderm Differentiation | ||||
| Nuclear Receptors | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Adipogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2640). | |||
| REF 2 | Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58. | |||
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