Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0PW7B
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| Former ID |
DIB019737
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| Drug Name |
DIDS
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| Synonyms |
4,4'-diisothiocyanostilbene-2,2'-disulphonic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H10N2O6S4
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| Canonical SMILES |
C1=CC(=C(C=C1N=C=S)S(=O)(=O)O)C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)O
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| InChI |
1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
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| InChIKey |
YSCNMFDFYJUPEF-OWOJBTEDSA-N
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| CAS Number |
CAS 152216-76-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:4286
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium-dependent chloride channel anoctamin (ANO) | Target Info | Blocker (channel blocker) | [2] |
| Chloride channel protein 6 (ClC-6) | Target Info | Blocker (channel blocker) | [3] | |
| Chloride channel protein 7 (ClC-7) | Target Info | Blocker (channel blocker) | [4] | |
| Chloride channel protein ClC-Ka (ClC-K1) | Target Info | Blocker (channel blocker) | [5] | |
| Chloride channel protein ClC-Kb (ClC-K2) | Target Info | Blocker (channel blocker) | [6] | |
| Volume regulated chloride channel (VRAC) | Target Info | Blocker (channel blocker) | [7] | |
| Reactome | Stimuli-sensing channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4177). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 705). | |||
| REF 4 | The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585. | |||
| REF 5 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 700). | |||
| REF 6 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 701). | |||
| REF 7 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). | |||
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