Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0PP6A
|
|||
| Drug Name |
ABT-165
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
AbbVieNorth Chicago, IL
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Delta-like protein 4 (DLL4) | Target Info | Inhibitor | [1] |
| Vascular endothelial growth factor (VEGF) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Notch signaling pathway | |||
| NetPath Pathway | Notch Signaling Pathway | |||
| Panther Pathway | Angiogenesis | |||
| Notch signaling pathway | ||||
| Pathway Interaction Database | Notch signaling pathway | |||
| Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | |||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
| Constitutive Signaling by NOTCH1 t(7 | ||||
| M1580_K2555) Translocation Mutant | ||||
| Constitutive Signaling by NOTCH1 HD Domain Mutants | ||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
| NOTCH2 Activation and Transmission of Signal to the Nucleus | ||||
| WikiPathways | Notch Signaling Pathway | |||
| Signaling by NOTCH3 | ||||
| Signaling by NOTCH4 | ||||
| Signaling by NOTCH1 | ||||
| Signaling by NOTCH2 | ||||
| Notch Signaling Pathway | ||||
| Neural Crest Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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