Drug Information
Drug General Information | Top | |||
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Drug ID |
D0P8RK
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Drug Name |
PMID27828716-Compound-16
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C14H8Cl3F3N4OS
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Canonical SMILES |
C1=CSC(=C1Cl)C2=C(C3=C(N2CCNC(=O)C(F)(F)F)C(=NC=N3)Cl)Cl
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InChI |
1S/C14H8Cl3F3N4OS/c15-6-1-4-26-11(6)9-7(16)8-10(12(17)23-5-22-8)24(9)3-2-21-13(25)14(18,19)20/h1,4-5H,2-3H2,(H,21,25)
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InChIKey |
OHSATPMXJJAETD-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Glycogen synthase kinase-3 alpha (GSK-3A) | Target Info | Inhibitor | [1] |
Target's Patent Info | Glycogen synthase kinase-3 alpha (GSK-3A) | Target's Patent Info | [1] | |
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Insulin/IGF pathway-protein kinase B signaling cascade | ||||
PDGF signaling pathway | ||||
Ras Pathway | ||||
Pathway Interaction Database | Degradation of beta catenin | |||
Canonical Wnt signaling pathway | ||||
FOXM1 transcription factor network | ||||
Class I PI3K signaling events mediated by Akt | ||||
Reactome | AKT phosphorylates targets in the cytosol | |||
XBP1(S) activates chaperone genes | ||||
Constitutive Signaling by AKT1 E17K in Cancer |
References | Top | |||
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REF 1 | Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. |
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