Drug Information
Drug General Information | Top | |||
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Drug ID |
D0P8DW
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Former ID |
DNC008971
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Drug Name |
A-943931
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Synonyms |
UNII-Q598HK01AO; A-943931; Q598HK01AO; 1027330-97-7; SCHEMBL602812; CHEMBL502347; BDBM26396; MolPort-035-936-414; SDTRYHWIXVHTLM-GFCCVEGCSA-N; ZINC40977166; NCGC00370827-02; 5H-Benzo(6,7)cyclohepta(1,2-d)pyrimidin-2-amine, 4-((3R)-3-amino-1-pyrrolidinyl)-6,7-dihydro-; 2,4-diamino-5,6-disubstituted pyrimidine, 10; 6-[(3R)-3-aminopyrrolidin-1-yl]-3,5-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2(7),3,5,11,13-hexaen-4-amine
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C17H21N5
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Canonical SMILES |
C1CC2=CC=CC=C2C3=C(C1)C(=NC(=N3)N)N4CCC(C4)N
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InChI |
1S/C17H21N5/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21)/t12-/m1/s1
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InChIKey |
SDTRYHWIXVHTLM-GFCCVEGCSA-N
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CAS Number |
CAS 1027330-97-7
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Histamine H4 receptor (H4R) | Target Info | Inhibitor | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | Histamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCR ligand binding | |||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and... J Med Chem. 2008 Oct 23;51(20):6547-57. |
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