Drug Information
Drug General Information | Top | |||
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Drug ID |
D0OL6O
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Former ID |
DAP001024
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Drug Name |
Methyl aminolevulinate
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Synonyms |
Metvix; Aminolevulinic acid methyl ester; Methyl 5-aminolevulinate; Methyl delta-aminolevulinate; Methyl5-amino-4-oxopentanoate; Levulinic acid, 5-amino-, methyl ester; Pentanoic acid, 5-amino-4-oxo-, methyl ester; 5-Aminolevulinic acid methyl ester
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Drug Type |
Small molecular drug
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Indication | Acne vulgaris [ICD-11: ED80; ICD-10: L70.0; ICD-9: 706.1] | Approved | [1], [2] | |
Therapeutic Class |
Anticancer Agents
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Structure |
Download2D MOL |
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Formula |
C6H11NO3
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Canonical SMILES |
COC(=O)CCC(=O)CN
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InChI |
1S/C6H11NO3/c1-10-6(9)3-2-5(8)4-7/h2-4,7H2,1H3
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InChIKey |
YUUAYBAIHCDHHD-UHFFFAOYSA-N
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CAS Number |
CAS 33320-16-0
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PubChem Compound ID | ||||
PubChem Substance ID |
3152707, 6729582, 10253237, 14747821, 46233440, 46507004, 50070563, 50071305, 50100968, 75370426, 96024892, 99333768, 103749693, 104171381, 113438636, 124883561, 124883562, 125824630, 126570614, 129851228, 132503116, 134221978, 134224946, 134338292, 135141172, 137127158, 142505868, 160964329, 165372994, 175268075, 179151184, 203088301, 223541399, 223817042, 225144187, 226399702
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ChEBI ID |
CHEBI:724125
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SuperDrug ATC ID |
L01XD03
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SuperDrug CAS ID |
cas=079416276
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Target and Pathway | Top | |||
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Target(s) | Ferrochelatase (FECH) | Target Info | Activator | [3] |
BioCyc | Heme biosynthesis | |||
Heme biosynthesis from uroporphyrinogen-III I | ||||
KEGG Pathway | Porphyrin and chlorophyll metabolism | |||
Metabolic pathways | ||||
Panther Pathway | Heme biosynthesis | |||
Pathwhiz Pathway | Porphyrin Metabolism | |||
Pathway Interaction Database | HIF-1-alpha transcription factor network | |||
WikiPathways | Heme Biosynthesis | |||
Metabolism of porphyrins |
References | Top | |||
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REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021415. | |||
REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 3 | Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo. Clin Cancer Res. 2009 May 15;15(10):3333-43. |
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