Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0OJ5M
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| Former ID |
DIB015946
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| Drug Name |
OLPADRONIC ACID SODIUM SALT
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| Synonyms |
Dimethyl-APD; IG-8801; Olpadronic acid sodium salt; 3-(Dimethylamino)-1-hydroxypropylidene-1,1-diphosphonic acid monosodium salt
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| Drug Type |
Small molecular drug
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| Indication | Bone resorption [ICD-11: FC0Z; ICD-10: M80] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C5H14NNaO7P2
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| Canonical SMILES |
CN(C)CCC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
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| InChI |
1S/C5H15NO7P2.Na/c1-6(2)4-3-5(7,14(8,9)10)15(11,12)13;/h7H,3-4H2,1-2H3,(H2,8,9,10)(H2,11,12,13);/q;+1/p-1
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| InChIKey |
DXTIBTHCHBZFJG-UHFFFAOYSA-M
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Geranyltranstransferase (FDPS) | Target Info | Modulator | [1] |
| BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
| Superpathway of cholesterol biosynthesis | ||||
| Trans, trans-farnesyl diphosphate biosynthesis | ||||
| Geranylgeranyldiphosphate biosynthesis | ||||
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Influenza A | ||||
| HTLV-I infection | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Cholesterol biosynthesis | |||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Cholesterol biosynthesis | |||
| Activation of gene expression by SREBF (SREBP) | ||||
| WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
| SREBP signalling | ||||
| Cholesterol Biosynthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo. Biochem Biophys Res Commun. 1999 Feb 16;255(2):491-4. | |||
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