Drug Information
Drug General Information | Top | |||
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Drug ID |
D0OB1J
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Former ID |
DAP001262
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Drug Name |
Diltiazem
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Synonyms |
Acalix; Adizem; Aldizem; Anoheal; Cardil; Cardizem; Citizem; Dilacor; Dilcontin; Dilren; Diltia; Diltiazemum; Dilticard; Diltzac; Dilzen; Endrydil; Viazem; Cardizen LA; Incoril AP; Tiazac Tildiem; Tiazac XC; Adizem (TN); Altiazem (TN); Angiozem (TN); Angizem (TN); Angizem CD (TN); Apo-Diltiaz; Cardizem (Hydrochloride); Cardizem (TN); Cartia XT (TN); Dilacor-XR; Dilatam (TN); Dilatem (TN); Dilcardia (TN); Dilcontin SR (TN); Dilt-cd; Dilta-Hexal; Diltelan (TN); Diltiazem (INN); Diltiazem [INN:BAN]; Diltiazemum [INN-Latin]; Diltime (TN); Dilzem (TN); Dyalec (TN); Filazem (TN); Herben (TN); Nu-Diltiaz; Progor (TN); RG 83606 (Hydrochloride); Surazem (TN); Tiamate (TN); Tiazac (TN); Tiazac XC (TN); Tildiem (TN); Vasmulax (TN); Viazem (TN); Zandil (TN); Zemtrial (TN); D-cis-Diltiazem; MK-793 (Malate); [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate; Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester; (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester; (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate; (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; (2S,3S)-5-[2-(dimethylamino)ethyl]-2-[4-(methyloxy)phenyl]-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1], [2] | |
Therapeutic Class |
Antihypertensive Agents
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Company |
Valeant International Barbados Srl
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Structure |
Download2D MOL |
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Formula |
C22H26N2O4S
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Canonical SMILES |
CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
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InChI |
1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
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InChIKey |
HSUGRBWQSSZJOP-RTWAWAEBSA-N
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CAS Number |
CAS 56209-45-1
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PubChem Compound ID | ||||
PubChem Substance ID |
9173, 596424, 3153198, 7979094, 8175919, 11113366, 11120251, 11120739, 11121227, 11466162, 11467282, 11485883, 14904463, 14929056, 25626811, 26751609, 26751610, 34705117, 46505667, 47364946, 47364947, 47959496, 48184777, 48258983, 48334236, 48415900, 49698365, 49890450, 50104266, 50104267, 50104268, 50104269, 50855582, 53788200, 57312277, 85306411, 85788735, 85788788, 89449648, 90341257, 92308825, 92309727, 92310310, 92711425, 93166706, 96024542, 99300641, 103164872, 103918269, 104331102
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ChEBI ID |
CHEBI:101278
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ADReCS Drug ID | BADD_D00674 ; BADD_D00675 | |||
SuperDrug ATC ID |
C08DB01
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SuperDrug CAS ID |
cas=042399417
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Interaction between the Drug and Microbe | Top | |||
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The Metabolism of Drug Affected by Studied Microbe(s) | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Alistipes indistinctus DSM22520
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -0.401; p = 0.025). | |||
Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.478; p = 0.011). | |||
Studied Microbe: Bacteroides ovatus ATCC 8483
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -1.207; p = 0.004). | |||
Studied Microbe: Bacteroides thetaiotaomicron
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[4] | |||
Hierarchy | ||||
Description | Diltiazem can be metabolized by Bacteroides thetaiotaomicron. | |||
Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -1.654; p = 0.001). | |||
Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -3.964; p = 0.004). | |||
Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -3.677; p = 0.006). | |||
Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.469; p = 0.02). | |||
Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -2.781; p = 0.001). | |||
Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.828; p = 0.003). | |||
Studied Microbe: Parabacteroides johnsonii DSM 18315
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.599; p = 0.012). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.448; p = 0.043). | |||
Studied Microbe: Clostridium sp.
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Clostridium sp. (log2FC = -0.396; p = 0.044). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
Studied Microbe: Victivallis vadensis ATCC BAA-548
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Diltiazem can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -0.453; p = 0.036). |
Target and Pathway | Top | |||
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Target(s) | Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) | Target Info | Blocker | [5] |
KEGG Pathway | MAPK signaling pathway | |||
Cardiac muscle contraction | ||||
Adrenergic signaling in cardiomyocytes | ||||
Oxytocin signaling pathway | ||||
Hypertrophic cardiomyopathy (HCM) | ||||
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||||
Dilated cardiomyopathy | ||||
Panther Pathway | Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||
WikiPathways | Arrhythmogenic Right Ventricular Cardiomyopathy | |||
miR-targeted genes in muscle cell - TarBase | ||||
miR-targeted genes in lymphocytes - TarBase |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2298). | |||
REF 2 | Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. PLoS Biol. 2008 Feb;6(2):e26. | |||
REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
REF 4 | Microbes make metabolic mischief by targeting drugs. Nature. 2019 Jun;570(7762):453-454. | |||
REF 5 | Egr-1, the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats. Cell Physiol Biochem. 2009;24(1-2):17-24. |
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