Drug Information
Drug General Information | Top | |||
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Drug ID |
D0O8YZ
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Former ID |
DNC011297
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Drug Name |
NSC-65069
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Synonyms |
Phloroglucide; 491-45-2; 2,3',4,5',6-Biphenylpentol; NSC-65069; 2-(3,5-dihydroxyphenyl)benzene-1,3,5-triol; [1,1'-Biphenyl]-2,3',4,5',6-pentaol; NSC65069; UNII-U4GNW4D2BR; U4GNW4D2BR; Phloroglucide hydrate; CHEMBL1288340; [1,1'-Biphenyl]-2,3',4,5',6-pentol; (1,1'-Biphenyl)-2,3',4,5',6-pentol; Biphenyl-2,3',4,5',6-pentaol; 2,3',4,5',6-Pentahydroxybiphenyl; biphenyl-2,3',4,5',6-pentol; phloroglucid; NSC 65069; AC1Q7AZY; AC1L6M6T; Phloroglucide hydrate, 95%; NCIOpen2_003126; 2,4,5',6-Biphenylpentol; SCHEMBL278516
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
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Download2D MOL |
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Formula |
C12H10O5
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Canonical SMILES |
C1=C(C=C(C=C1O)O)C2=C(C=C(C=C2O)O)O
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InChI |
1S/C12H10O5/c13-7-1-6(2-8(14)3-7)12-10(16)4-9(15)5-11(12)17/h1-5,13-17H
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InChIKey |
KICYRZIVKKYRFS-UHFFFAOYSA-N
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CAS Number |
CAS 491-45-2
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Quinone reductase 1 (NQO1) | Target Info | Inhibitor | [1] |
KEGG Pathway | Ubiquinone and other terpenoid-quinone biosynthesis | |||
NetPath Pathway | TCR Signaling Pathway | |||
Pathwhiz Pathway | Vitamin K Metabolism | |||
Pathway Interaction Database | Validated transcriptional targets of TAp63 isoforms | |||
WikiPathways | Estrogen metabolism | |||
Oxidative Stress | ||||
Transcriptional activation by NRF2 | ||||
NRF2 pathway | ||||
Nuclear Receptors Meta-Pathway | ||||
Aryl Hydrocarbon Receptor Pathway | ||||
Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
Metabolism of amino acids and derivatives | ||||
Aryl Hydrocarbon Receptor | ||||
Dopamine metabolism | ||||
Arylhydrocarbon receptor (AhR) signaling pathway |
References | Top | |||
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REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. |
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