Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0O7QA
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| Former ID |
DIB012012
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| Drug Name |
PF-05089771
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| Synonyms |
Nav1.7 blockers (pain), Pfizer; SCN9A blockers (pain), Pfizer/Icagen/Birkbeck; Voltage-gated sodium channel 1.7 blockers (pain), Pfizer
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| Indication | Chronic pain [ICD-11: MG30; ICD-10: R52.1, R52.2; ICD-9: 338.2, 780] | Phase 2 | [1] | |
| Company |
Pfizer
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| Structure |
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Download2D MOL |
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| Formula |
C18H12Cl2FN5O3S2
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| Canonical SMILES |
C1=CC(=C(C=C1Cl)C2=C(NN=C2)N)OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=CSC=N4)F
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| InChI |
1S/C18H12Cl2FN5O3S2/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17/h1-8,26H,(H3,22,24,25)
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| InChIKey |
ZYSCOUXLBXGGIM-UHFFFAOYSA-N
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| CAS Number |
CAS 1235403-62-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated sodium channel alpha Nav1.7 (SCN9A) | Target Info | Blocker | [2] |
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01529346) Efficacy Of PF-05089771 In Treating Postoperative Dental Pain. U.S. National Institutes of Health. | |||
| REF 2 | Primary erythromelalgia: a review. Orphanet J Rare Dis. 2015 Sep 30;10:127. | |||
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