Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0O6ZH
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| Drug Name |
Endo-CD
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| Synonyms |
Endostatin-cytosine deaminase fusion protein
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Endostatin (COL18A1) | Target Info | Modulator | [1] |
| KEGG Pathway | Protein digestion and absorption | |||
| NetPath Pathway | FSH Signaling Pathway | |||
| Pathway Interaction Database | Beta1 integrin cell surface interactions | |||
| Direct p53 effectors | ||||
| Validated nuclear estrogen receptor alpha network | ||||
| FOXA1 transcription factor network | ||||
| Reactome | Collagen degradation | |||
| Activation of Matrix Metalloproteinases | ||||
| Collagen biosynthesis and modifying enzymes | ||||
| Assembly of collagen fibrils and other multimeric structures | ||||
| Integrin cell surface interactions | ||||
| Laminin interactions | ||||
| WikiPathways | Assembly of collagen fibrils and other multimeric structures | |||
| Activation of Matrix Metalloproteinases | ||||
| Collagen biosynthesis and modifying enzymes | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase.Mol Cancer Ther.2011 Aug;10(8):1327-36. | |||
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