Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O6UZ
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| Former ID |
DAP001270
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| Drug Name |
Sertaconazole
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| Synonyms |
Sertaconazol; Sertaconazolum; Sertaconazol [Spanish]; Sertaconazole [INN]; Sertaconazolum [Latin]; FI-7045; Sertaconazole (INN); (+-)-1-(2,4-Dichloro-beta-((7-chlorobenzo(b)thien-3-yl)methoxy)phenethyl)imidazole; (inverted exclamation markA)-1-[2,4-dichloro-b-[(7-chlorobenzo[b]thien-3-yl)methoxy]phenethyl]imidazole;1-(2-((7-Chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; 1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; 7-Chloro-3-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy-methyl)benzo(b)thiophene; 7-Chloro-3-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy-methyl]benzo[b]thiophene; 7-Cloro-3-(1-(2,4-diclorofenil)-2-(1H-imidazol-1-il)etoxi-metil)benzo(b)tiofeno; 7-Cloro-3-(1-(2,4-diclorofenil)-2-(1H-imidazol-1-il)etoxi-metil)benzo(b)tiofeno [Spanish]
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| Drug Type |
Small molecular drug
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| Indication | Fungal infection [ICD-11: 1F29-1F2F; ICD-10: B35-B49; ICD-9: 110-118] | Approved | [1] | |
| Therapeutic Class |
Antifungal Agents
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| Structure |
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Download2D MOL |
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| Formula |
C20H15Cl3N2OS
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| Canonical SMILES |
C1=CC2=C(C(=C1)Cl)SC=C2COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl
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| InChI |
1S/C20H15Cl3N2OS/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22/h1-8,11-12,19H,9-10H2
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| InChIKey |
JLGKQTAYUIMGRK-UHFFFAOYSA-N
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| CAS Number |
CAS 99592-32-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
603554, 7980591, 8189993, 11467073, 11468193, 11486641, 14807917, 43122603, 46507290, 47424427, 47424428, 47795245, 48094743, 49661783, 49699265, 49979301, 50124067, 50801836, 57315786, 85788090, 92308932, 92721890, 104334862, 117462247, 124766162, 126423515, 126618759, 126663270, 128291326, 134338506, 135026063, 136930119, 137146643, 140684369, 151989702, 160964487, 162755106, 164814798, 171578527, 176484071, 179151516, 184021083, 198992756, 206245878, 223402966, 223448369, 223686739, 224234871, 226447109, 241170318
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| ChEBI ID |
CHEBI:83682
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| ADReCS Drug ID | BADD_D02008 ; BADD_D02009 | |||
| SuperDrug ATC ID |
D01AC14
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| SuperDrug CAS ID |
cas=099592322
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Prevotella copri
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Sertaconazole nitrate (adjusted p-values: 2.80E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Sertaconazole nitrate (adjusted p-values: 2.73E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Sertaconazole nitrate (adjusted p-values: 7.71E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Sertaconazole nitrate (adjusted p-values: 1.43E-06). | |||
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Studied Microbe: Clostridium perfringens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Sertaconazole nitrate (adjusted p-values: 1.73E-05). | |||
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Studied Microbe: Coprococcus comes
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Sertaconazole nitrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Dorea formicigenerans
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Sertaconazole nitrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Enterocloster bolteae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Sertaconazole nitrate (adjusted p-values: 3.28E-04). | |||
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Studied Microbe: Eubacterium eligens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Sertaconazole nitrate (adjusted p-values: 1.14E-05). | |||
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Studied Microbe: Eubacterium rectale
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Sertaconazole nitrate (adjusted p-values: 1.71E-04). | |||
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Studied Microbe: Roseburia hominis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Sertaconazole nitrate (adjusted p-values: 1.95E-05). | |||
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Studied Microbe: Roseburia intestinalis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Sertaconazole nitrate (adjusted p-values: 1.57E-04). | |||
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Studied Microbe: Ruminococcus bromii
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Sertaconazole nitrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Ruminococcus gnavus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Sertaconazole nitrate (adjusted p-values: 5.71E-06). | |||
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Studied Microbe: Ruminococcus torques
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Sertaconazole nitrate (adjusted p-values: 1.01E-04). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Candida Cytochrome P450 51 (Candi ERG11) | Target Info | Inhibitor | [3] |
| References | Top | |||
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| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021385. | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009;69(3):339-59. | |||
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