Drug Information
Drug General Information | Top | |||
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Drug ID |
D0O6NS
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Former ID |
DNC008827
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Drug Name |
8-Br-adenine
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Synonyms |
8-Bromoadenine; 8-bromo-7H-purin-6-amine; 6974-78-3; 8-Bromo-9H-purin-6-amine; 8-Br-adenine; 8-Bromo-1H-adenine; 6-Amino-8-bromopurine; 8-bromopurine-6-ylamine; EINECS 230-225-1; NSC 21697; CHEMBL65747; 8-Bromo-9H-purin-6-ylamine; FVXHPCVBOXMRJP-UHFFFAOYSA-N; W-203555; 1H-Purin-6-amine, 8-bromo-; 8-bromo-1h-purin-6-amine; 8-bromadenin; 8-Bromo adenine; SCHEMBL8565; AC1L31DI; Oprea1_043695; 8-Bromo-9H-purine-6-amine; 9H-Purin-6-amine,2-bromo-; 9H-Purin-6-amine,8-bromo-; 8-Bromo-9H-purin-6-amine #; CTK4G0895; DTXSID70220036
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C5H4BrN5
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Canonical SMILES |
C1=NC(=C2C(=N1)N=C(N2)Br)N
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InChI |
1S/C5H4BrN5/c6-5-10-2-3(7)8-1-9-4(2)11-5/h1H,(H3,7,8,9,10,11)
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InChIKey |
FVXHPCVBOXMRJP-UHFFFAOYSA-N
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CAS Number |
CAS 6974-78-3
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Inhibitor | [1] |
KEGG Pathway | Rap1 signaling pathway | |||
Calcium signaling pathway | ||||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | ||||
Parkinson's disease | ||||
Alcoholism | ||||
Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
Reactome | NGF-independant TRKA activation | |||
Adenosine P1 receptors | ||||
G alpha (s) signalling events | ||||
Surfactant metabolism | ||||
WikiPathways | Nucleotide GPCRs | |||
Monoamine Transport | ||||
GPCRs, Class A Rhodopsin-like | ||||
NGF signalling via TRKA from the plasma membrane | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. |
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