Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O2DQ
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| Former ID |
DNC000925
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| Drug Name |
Mepacrine
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| Synonyms |
quinacrine; mepacrine; atabrine; Acrinamine; Acriquine; 83-89-6; Quinactine; Antimalarina; Haffkinine; Akrichin; Italchine; acrichine; Erion; Mepacrinum; Quinacrine hydrochloride; Mepacrine [INN:BAN]; St 439; Mepacrinum [INN-Latin]; Mepacrina [INN-Spanish]; atebrin; Malaricida; Methoquine; Palacrin; Italchin; Pentilen; Palusan; Atebrine; Metochin; Mecryl; Quinacrine, Mepacrine; 3-Chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine; 2-Methoxy-6-chloro-9-diethylaminopentylaminoacridine; HSDB 3253
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H30ClN3O
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| Canonical SMILES |
CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
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| InChI |
1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
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| InChIKey |
GPKJTRJOBQGKQK-UHFFFAOYSA-N
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| CAS Number |
CAS 83-89-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9546, 598066, 3138736, 5198883, 8150522, 10589337, 11335276, 11360515, 11363823, 11364917, 11366385, 11367479, 11368947, 11370041, 11371712, 11373080, 11374150, 11375641, 11377109, 11378211, 11405321, 11461487, 11466346, 11467466, 11484412, 11486271, 11488704, 11490422, 11492311, 11494743, 11533330, 14781277, 24262994, 24438614, 25820836, 46507828, 47365028, 47440097, 47736309, 48034955, 48034956, 48110303, 48110304, 48184845, 48334330, 48415587, 49698889, 49864262, 50111199, 53790823
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| ChEBI ID |
CHEBI:8711
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| SuperDrug ATC ID |
P01AX05
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| SuperDrug CAS ID |
cas=000083896
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Quinacrine dihydrochloride dihydrate (adjusted p-values: 1.54E-04). | |||
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Studied Microbe: Parabacteroides distasonis
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Quinacrine dihydrochloride dihydrate (adjusted p-values: 1.00E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Coprococcus comes
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Quinacrine dihydrochloride dihydrate (adjusted p-values: 2.05E-03). | |||
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Studied Microbe: Enterocloster bolteae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Quinacrine dihydrochloride dihydrate (adjusted p-values: 8.67E-03). | |||
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Studied Microbe: Roseburia hominis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Quinacrine dihydrochloride dihydrate (adjusted p-values: 8.23E-04). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phospholipase A2 (PLA2G1B) | Target Info | Inhibitor | [1] |
| BioCyc | Phospholipases | |||
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Ether lipid metabolism | ||||
| Arachidonic acid metabolism | ||||
| Linoleic acid metabolism | ||||
| alpha-Linolenic acid metabolism | ||||
| Metabolic pathways | ||||
| Ras signaling pathway | ||||
| Vascular smooth muscle contraction | ||||
| Pancreatic secretion | ||||
| Fat digestion and absorption | ||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
| Reactome | Acyl chain remodelling of PC | |||
| Acyl chain remodelling of PE | ||||
| Acyl chain remodelling of PI | ||||
| WikiPathways | Glycerophospholipid biosynthesis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Involvement of protein kinase C activation in L-leucine-induced stimulation of protein synthesis in l6 myotubes. Cytotechnology. 2003 Nov;43(1-3):97-103. | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
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