Drug Information
Drug General Information | Top | |||
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Drug ID |
D0O1DS
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Former ID |
DIB015362
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Drug Name |
[123I] iodobenzoyl 12-Ex4
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Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Investigative | [1], [2], [3] | |
Company |
Kyoto University
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Target and Pathway | Top | |||
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Target(s) | Glucagon-like peptide 1 receptor (GLP1R) | Target Info | Modulator | [1], [2], [3] |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Insulin secretion | ||||
Reactome | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | |||
G alpha (s) signalling events | ||||
Glucagon-type ligand receptors | ||||
WikiPathways | GPCRs, Class B Secretin-like | |||
Integration of energy metabolism | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). | |||
REF 2 | Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)--preclinical and clinical results. Best Pract Res Clin Endocrinol Metab. 2009 Aug;23(4):463-77. | |||
REF 3 | Bydureon: first once weekly GLP-1 receptor agonist (exenatide LAR). Rev Med Liege. 2014 Apr;69(4):214-9. |
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