Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0O0BR
|
|||
| Former ID |
DIB003304
|
|||
| Drug Name |
Poly-ICR
|
|||
| Synonyms |
Poly-ICR (topical, keratosis/genital warts); Poly-ICR (topical, keratosis/genital warts), Akela; Poly-ICR (topical, keratosis/genital warts), Nventa; TLR-3 agonist (topical, acitinic keratosis/genital warts), Nventa; Poly IC-poly-arginine (topical, keratosis/genital warts), Nventa
Click to Show/Hide
|
|||
| Indication | Keratosis [ICD-11: ED56; ICD-10: L57.0] | Investigative | [1] | |
| Company |
Nventa Biopharmaceuticals Corp
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Toll-like receptor 3 (TLR3) | Target Info | Agonist | [1] |
| KEGG Pathway | Toll-like receptor signaling pathway | |||
| Hepatitis C | ||||
| Hepatitis B | ||||
| Influenza A | ||||
| Herpes simplex infection | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Toll receptor signaling pathway | |||
| Pathway Interaction Database | Endogenous TLR signaling | |||
| Reactome | Ligand-dependent caspase activation | |||
| MyD88-independent TLR3/TLR4 cascade | ||||
| Trafficking and processing of endosomal TLR | ||||
| RIP-mediated NFkB activation via ZBP1 | ||||
| TRIF-mediated programmed cell death | ||||
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
| IKK complex recruitment mediated by RIP1 | ||||
| TRAF6 mediated induction of TAK1 complex | ||||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Toll-Like Receptors Cascades | ||||
| MyD88-independent cascade | ||||
| Trafficking and processing of endosomal TLR | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753). | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.