Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0NS6S
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| Drug Name |
Cyclopenta[d]pyrimidine derivative 1
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| Synonyms |
PMID28270010-Compound-Figure28
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| Drug Type |
Small molecular drug
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| Company |
MEDIVATION TECHNOLOGIES, INC
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H27FN8O
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| Canonical SMILES |
CC(C)C1=CC(=NN1)NC2=NC(=NC3=C2CCC3)N4CCCC4C(=O)NC5=CN=C(C=C5)F
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| InChI |
1S/C23H27FN8O/c1-13(2)17-11-20(31-30-17)28-21-15-5-3-6-16(15)27-23(29-21)32-10-4-7-18(32)22(33)26-14-8-9-19(24)25-12-14/h8-9,11-13,18H,3-7,10H2,1-2H3,(H,26,33)(H2,27,28,29,30,31)
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| InChIKey |
GZDATWXVIVEVAM-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | BDNF/NT-3 growth factors receptor (TrkB) | Target Info | Inhibitor | [1] |
| NT-3 growth factor receptor (TrkC) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | BDNF/NT-3 growth factors receptor (TrkB) | Target's Patent Info | [1] | |
| NT-3 growth factor receptor (TrkC) | Target's Patent Info | [1] | ||
| KEGG Pathway | MAPK signaling pathway | |||
| Neurotrophin signaling pathway | ||||
| Alcoholism | ||||
| Pathway Interaction Database | SHP2 signaling | |||
| Posttranslational regulation of adherens junction stability and dissassembly | ||||
| Neurotrophic factor-mediated Trk receptor signaling | ||||
| Reactome | NGF-independant TRKA activation | |||
| ARMS-mediated activation | ||||
| PI3K/AKT activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| BDNF signaling pathway | ||||
| MAPK Signaling Pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. | |||
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