Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0NS6H
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| Former ID |
DIB013501
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| Drug Name |
Donepezil
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| Synonyms |
Donepezil (transdermal patch, Alzheimer's disease)
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Neurology Agents
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| Company |
Nitto Denko Corp
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H29NO3
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| Canonical SMILES |
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
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| InChI |
1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
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| InChIKey |
ADEBPBSSDYVVLD-UHFFFAOYSA-N
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| CAS Number |
CAS 120014-06-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4396592, 7979121, 8152007, 11364558, 11367120, 11369682, 11377844, 11495478, 14829295, 29222294, 46504803, 46509735, 47526357, 47673582, 49830545, 49982851, 50112790, 50803390, 57321637, 81041121, 85730950, 92711664, 96024565, 103172342, 103853425, 104302675, 104825734, 121264514, 121291395, 125333679, 126525333, 126584296, 126584297, 126630639, 126657167, 126663241, 126670558, 127318381, 127318382, 127318383, 127318384, 127318385, 127318386, 127318387, 127318388, 127318389, 127318390, 127318391, 127318392, 127318393
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| ChEBI ID |
CHEBI:53289
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| ADReCS Drug ID | BADD_D00706 ; BADD_D00707 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetylcholinesterase (AChE) | Target Info | Modulator | [4] |
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Cholinergic synapse | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| Pathwhiz Pathway | Phospholipid Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| WikiPathways | Monoamine Transport | |||
| Biogenic Amine Synthesis | ||||
| Acetylcholine Synthesis | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6599). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001402) | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465). | |||
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