Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NI4Z
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| Former ID |
DNC004186
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| Drug Name |
7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
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| Synonyms |
CHEMBL98851; 7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one; SCHEMBL10758208; 2H-Imidazo[4,5-b]quinolin-2-one, 7-chloro-1,3-dihydro-; BDBM50007221
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H6ClN3O
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| Canonical SMILES |
C1=CC2=NC3=C(C=C2C=C1Cl)NC(=O)N3
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| InChI |
1S/C10H6ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
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| InChIKey |
OSBMKBWTTUTUMA-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 3A (PDE3A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Purine metabolism | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | cGMP effects | |||
| G alpha (s) signalling events | ||||
| WikiPathways | miR-targeted genes in muscle cell - TarBase | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. | |||
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