Drug Information
Drug General Information | Top | |||
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Drug ID |
D0NF1U
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Former ID |
DNC013905
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Drug Name |
FENOFIBRIC ACID
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Synonyms |
Fenofibric acid; 42017-89-0; Procetofenic acid; 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid; alpha 1081; NSC 281318; LF 178 acid; UNII-BGF9MN2HU1; 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid; LF 153; FNF Acid; C17H15ClO4; Trilipix; CCRIS 7302; EINECS 255-626-9; BGF9MN2HU1; CHEMBL981; BRN 2058973; CHEBI:83469; 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic Acid; Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-; AK117112; 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoic acid; W-106287
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Drug Type |
Small molecular drug
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Indication | Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99, E78; ICD-9: 390-459] | Approved | [1] | |
Structure |
Download2D MOL |
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Formula |
C17H15ClO4
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Canonical SMILES |
CC(C)(C(=O)O)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
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InChI |
1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
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InChIKey |
MQOBSOSZFYZQOK-UHFFFAOYSA-N
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CAS Number |
CAS 42017-89-0
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PubChem Compound ID | ||||
PubChem Substance ID |
143270, 7671261, 8189389, 15988368, 29203742, 43121787, 50022223, 50826157, 56312055, 56314036, 58097888, 81049613, 85171876, 87359585, 103256438, 103853918, 104332417, 118048388, 118212615, 125350317, 126616576, 126650397, 126665945, 128633517, 134351110, 135023245, 135650256, 136990671, 137008576, 139809304, 143755763, 152028908, 162175168, 162263030, 163415486, 164785582, 172913777, 174529345, 175265316, 175611044, 184538157, 187072366, 198991585, 210279847, 210282170, 223352414, 223385806, 223448217, 223519115, 223669964
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ChEBI ID |
CHEBI:83469
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ADReCS Drug ID | BADD_D00874 |
Target and Pathway | Top | |||
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Target(s) | Fatty acid-binding protein 1 (FABP1) | Target Info | Inhibitor | [2] |
KEGG Pathway | PPAR signaling pathway | |||
Fat digestion and absorption | ||||
Reactome | Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | |||
PPARA activates gene expression | ||||
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
WikiPathways | Nuclear Receptors Meta-Pathway | |||
PPAR Alpha Pathway | ||||
Selenium Metabolism and Selenoproteins | ||||
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2662). | |||
REF 2 | Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10;51(13):3755-64. |
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