Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N8RM
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| Former ID |
DNC008835
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| Drug Name |
9-(2-Hydroxyethyl)-9H-adenine
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| Synonyms |
2-(6-aminopurin-9-yl)ethanol; 707-99-3; 9-(2-Hydroxyethyl)adenine; 9h-purine-9-ethanol, 6-amino-; 9-(2-hydroxyethyl) adenine; CHEMBL95897; 6-Amino-9H-purin-9-ethanol; VAQOTZQDXZDBJK-UHFFFAOYSA-N; 6-Amino-9-(2-hydroxyethyl)purine; 2-(6-Amino-9H-purin-9-yl)ethanol; 9-(2-Hydroxyethyl)-9H-adenine; NSC51467; N9 -hydroxyethyladenine; AC1Q4VHV; 9-(2hydroxyethyl)adenine; ACMC-209og5; TimTec1_003634; 9-(2'-hydroxyethyl)adenine; 9-(2-Hydroxyethyl)adenine.; SCHEMBL984944; 6-Amino-9h-purine-9-ethanol; AC1L69W8; ZINC36416; KS-00000VZR
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C7H9N5O
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| Canonical SMILES |
C1=NC(=C2C(=N1)N(C=N2)CCO)N
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| InChI |
1S/C7H9N5O/c8-6-5-7(10-3-9-6)12(1-2-13)4-11-5/h3-4,13H,1-2H2,(H2,8,9,10)
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| InChIKey |
VAQOTZQDXZDBJK-UHFFFAOYSA-N
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| CAS Number |
CAS 707-99-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Calcium signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | ||||
| Parkinson's disease | ||||
| Alcoholism | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Reactome | NGF-independant TRKA activation | |||
| Adenosine P1 receptors | ||||
| G alpha (s) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Nucleotide GPCRs | |||
| Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. | |||
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