Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N5YD
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Former ID |
DNCL003041
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Drug Name |
Nepicastat oral
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Synonyms |
SYN117
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Drug Type |
Small molecular drug
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Indication | Post-traumatic stress disorder [ICD-11: 6B40; ICD-10: F43.1, F62.0; ICD-9: 309.81, 304.2] | Phase 2 | [1], [2] | |
Company |
Biotie Therapies
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Structure |
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Download2D MOL |
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Formula |
C14H16ClF2N3S
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Canonical SMILES |
C1CC2=C(CC1N3C(=CNC3=S)CN)C=C(C=C2F)F.Cl
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InChI |
1S/C14H15F2N3S.ClH/c15-9-3-8-4-10(1-2-12(8)13(16)5-9)19-11(6-17)7-18-14(19)20;/h3,5,7,10H,1-2,4,6,17H2,(H,18,20);1H/t10-;/m0./s1
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InChIKey |
DIPDUAJWNBEVOY-PPHPATTJSA-N
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CAS Number |
CAS 170151-24-3
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Dopamine beta hydroxylase (DBH) | Target Info | Inhibitor | [3] |
BioCyc | Catecholamine biosynthesis | |||
KEGG Pathway | Tyrosine metabolism | |||
Metabolic pathways | ||||
Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
Dopamine receptor mediated signaling pathway | ||||
Pathwhiz Pathway | Catecholamine Biosynthesis | |||
Tyrosine Metabolism | ||||
WikiPathways | Monoamine Transport | |||
Biogenic Amine Synthesis | ||||
Metabolism of amino acids and derivatives |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00641511) Pharmacogenetic Clinical Trial of Nepicastat for Post Traumatic Stress Disorder (PTSD). U.S. National Institutes of Health. | |||
REF 2 | ClinicalTrials.gov (NCT01704196) A Multi-Center Trial of Nepicastat for Cocaine Dependence. U.S. National Institutes of Health. | |||
REF 3 | Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol. 1997 Aug;121(8):1803-9. |
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