Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N3XT
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| Former ID |
DNC006030
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| Drug Name |
BREQUINAR
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| Synonyms |
Brequinar; 96187-53-0; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; brequinarum [Latin]; Brequinar [INN]; Biphenquinate; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; Brequinarum [INN-Latin]; UNII-5XL19F49H6; C23H15F2NO2; NSC-368390; NSC 368390; 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid; PHEZJEYUWHETKO-UHFFFAOYSA-N; Dup 785; 5XL19F49H6; 6-FLUORO-2-(2'-FLUORO-1,1'-BIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID; brequinarum
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| Drug Type |
Small molecular drug
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| Indication | Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Phase 2 | [1] | |
| Acute myeloid leukaemia [ICD-11: 2A60; ICD-9: 205] | Phase 1/2 | [2] | ||
| Structure |
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Download2D MOL |
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| Formula |
C23H15F2NO2
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| Canonical SMILES |
CC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O
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| InChI |
1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28)
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| InChIKey |
PHEZJEYUWHETKO-UHFFFAOYSA-N
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| CAS Number |
CAS 96187-53-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
604688, 833552, 5141941, 7886333, 8185015, 11407783, 14779823, 43114774, 46504783, 46515644, 47960438, 50065413, 57313868, 78503079, 96099826, 103216339, 104311590, 126421111, 128915510, 134343235, 135030617, 137220339, 141792749, 152200612, 152343569, 152343570, 160825160, 160966637, 162011531, 162150672, 162201837, 163092469, 163384428, 163840377, 163884586, 170558732, 171063036, 174531766, 178103978, 179151469, 198976397, 202565961, 204383117, 223402609, 223536769, 226433170, 241168208, 242060369, 250121679
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dihydroorotate dehydrogenase (DHODH) | Target Info | Modulator | [3] |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Panther Pathway | De novo pyrimidine ribonucleotides biosythesis | |||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04575038) CRISIS2: A Phase 2 Study of the Safety and Antiviral Activity of Brequinar in Non-hospitalized Pts With COVID-19 (CRISIS2). U.S. National Institutes of Health. | |||
| REF 2 | ClinicalTrials.gov (NCT03760666) A Study of Brequinar in Subjects With Relapsed/Refractory Acute Myeloid Leukemia. U.S. National Institutes of Health. | |||
| REF 3 | DOI: 10.1203/00006450-198807000-00137 | |||
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