Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N2DJ
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Drug Name |
Benzimidazole derivative 11
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Synonyms |
PMID28627961-Compound-10
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Drug Type |
Small molecular drug
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Company |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH PRIEPKE, Henning DOODS, Henri KUELZER, Raimund PFAU, Roland STENKAMP, Dirk PELCMAN, Benjamin ROENN, Robert
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Structure |
Download2D MOL |
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Formula |
C29H28Cl3F2N5O3
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Canonical SMILES |
CC(C)(C)C(=O)NCC1=C(C(=C(C=C1)Cl)NC2=NC3=C(N2C)C=C(C(=C3)C(=O)NC4=CC(=C(C=C4)F)Cl)OCCF)Cl
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InChI |
1S/C29H28Cl3F2N5O3/c1-29(2,3)27(41)35-14-15-5-7-18(30)25(24(15)32)38-28-37-21-12-17(23(42-10-9-33)13-22(21)39(28)4)26(40)36-16-6-8-20(34)19(31)11-16/h5-8,11-13H,9-10,14H2,1-4H3,(H,35,41)(H,36,40)(H,37,38)
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InChIKey |
MJNRUPMNPGZLRT-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Prostaglandin E synthase (PTGES) | Target Info | Inhibitor | [1] |
Target's Patent Info | Prostaglandin E synthase (PTGES) | Target's Patent Info | [1] | |
BioCyc | C20 prostanoid biosynthesis | |||
KEGG Pathway | Arachidonic acid metabolism | |||
Metabolic pathways | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
TCR Signaling Pathway | ||||
Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
WikiPathways | Arachidonic acid metabolism | |||
Eicosanoid Synthesis |
References | Top | |||
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REF 1 | Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. |
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