Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N1ST
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| Former ID |
DIB007214
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| Drug Name |
AFC-5128
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| Synonyms |
AFC-5261; P2X7 purinoreceptor antagonists (neuropathic pain/ multiple sclerosis); P2X7 purinoreceptor antagonist (inflammatory disease/neurodegenerative disorder), Affectis; P2X7 purinoreceptor antagonists (neuropathic pain/ multiple sclerosis), Affectis
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| Indication | Autoimmune diabetes [ICD-11: 5A10] | Investigative | [1] | |
| Company |
Affectis Pharmaceuticals AG
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2X purinoceptor 7 (P2RX7) | Target Info | Antagonist | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | The NLRP3 inflammasome | |||
| WikiPathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484). | |||
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