Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N1PZ
|
|||
| Former ID |
DIB013274
|
|||
| Drug Name |
S-tenatoprazole
|
|||
| Synonyms |
Benatoprazole; Protop; Tenatoprazole; Ulsacare; STU-199; STU-Na; TU-199; S-tenatoprazole-Na
Click to Show/Hide
|
|||
| Indication | Peptic ulcer [ICD-11: DA61] | Phase 2 | [1] | |
| Company |
Mitsubishi-Tokyo Pharmaceuticals Inc
|
|||
| Structure |
 |
Download2D MOL |
||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Alistipes indistinctus DSM22520
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -7.888; p = 0.006). | |||
|
Studied Microbe: Bacteroides caccae ATCC 43185
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -7.126; p = 0.016). | |||
|
Studied Microbe: Bacteroides cellulosilyticus DSM 14838
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -9.068; p = 0.003). | |||
|
Studied Microbe: Bacteroides coprophilus DSM 18228
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -8.345; p = 0.007). | |||
|
Studied Microbe: Bacteroides dorei DSM 17855
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -9.32; p = 0.003). | |||
|
Studied Microbe: Bacteroides eggerthii DSM20697
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -6.675; p = 0.037). | |||
|
Studied Microbe: Bacteroides finegoldii DSM17565
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -6.407; p = 0.016). | |||
|
Studied Microbe: Bacteroides fragilis ATCC43859
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -8.928; p = 0.003). | |||
|
Studied Microbe: Bacteroides fragilis HMW 610
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -9.334; p = 0.005). | |||
|
Studied Microbe: Bacteroides fragilis HMW 615
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -8.709; p = 0.004). | |||
|
Studied Microbe: Bacteroides fragilis NCTC 9343
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -8.804; p = 0.012). | |||
|
Studied Microbe: Bacteroides fragilis str. 3397 T10
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -7.57; p = 0.007). | |||
|
Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -6.244; p = 0.004). | |||
|
Studied Microbe: Bacteroides fragilis str. DS-208
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -6.117; p = 0.048). | |||
|
Studied Microbe: Bacteroides intestinalis DSM 17393
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -8.042; p = 0.017). | |||
|
Studied Microbe: Bacteroides ovatus ATCC 8483
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -7.433; p = 0.009). | |||
|
Studied Microbe: Bacteroides stercoris ATCC 43183
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -6.877; p = 0.025). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 3731
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -7.406; p = 0.007). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron 7330
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -7.404; p = 0.005). | |||
|
Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -4.67; p = 0.004). | |||
|
Studied Microbe: Bacteroides uniformis ATCC 8492
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -8.086; p = 0.021). | |||
|
Studied Microbe: Bacteroides vulgatus ATCC 8482
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -9.1; p = 0.003). | |||
|
Studied Microbe: Bacteroides WH2
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides WH2 (log2FC = -7.595; p = 0.009). | |||
|
Studied Microbe: Bacteroides xylanisolvens DSM18836
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -8.024; p = 0.013). | |||
|
Studied Microbe: Odoribacter splanchnicus
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Odoribacter splanchnicus (log2FC = -7.638; p = 0.003). | |||
|
Studied Microbe: Parabacteroides distasonis ATCC 8503
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -8.687; p = 0.012). | |||
|
Studied Microbe: Parabacteroides merdae ATCC 43184
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -8.12; p = 0.006). | |||
|
Studied Microbe: Pretovella copri DSM 18205
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Pretovella copri DSM 18205 (log2FC = -7.833; p = 0.02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
|
Studied Microbe: Bifidobacterium adolescentis ATCC 15703
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -6.097; p = 0.011). | |||
|
Studied Microbe: Bifidobacterium breve DSM 20213
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -7.611; p = 0.04). | |||
|
Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -8.44; p = 0.002). | |||
|
Studied Microbe: Bifidobacterium ruminantium
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bifidobacterium ruminantium (log2FC = -8.491; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
|
Studied Microbe: Collinsella aerofaciens ATCC25986
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -7.523; p = 0.0). | |||
|
Studied Microbe: Collinsella intestinalis DSM 13280
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -7.158; p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
|
Studied Microbe: Eggerthella lenta ATCC 25559
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -6.131; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
|
Studied Microbe: Edwardsiella tarda ATCC 23685
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -5.248; p = 0.002). | |||
|
Studied Microbe: Enterobacter cancerogenus ATCC35316
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -6.892; p = 0.003). | |||
|
Studied Microbe: Escherichia coli BW25113
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Escherichia coli BW25113 (log2FC = -6.763; p = 0.017). | |||
|
Studied Microbe: Proteus penneri ATCC 35198
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Proteus penneri ATCC 35198 (log2FC = -4.848; p = 0.002). | |||
|
Studied Microbe: Providencia alcalifaciens DSM 30120
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Providencia alcalifaciens DSM 30120 (log2FC = -7.831; p = 0.003). | |||
|
Studied Microbe: Providencia rettgeri DSM 1131
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Providencia rettgeri DSM 1131 (log2FC = -7.717; p = 0.004). | |||
|
Studied Microbe: Providencia stuartii ATCC 25827
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Providencia stuartii ATCC 25827 (log2FC = -7.048; p = 0.003). | |||
|
Studied Microbe: Salmonella typhimurium LT2
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Salmonella typhimurium LT2 (log2FC = -5.716; p = 0.029). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
|
Studied Microbe: Clostridium ramosum DSM 1402
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -6.59; p = 0.011). | |||
|
Studied Microbe: Clostridium spiroforme DSM1552
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -7.744; p = 0.003). | |||
|
Studied Microbe: Eubacterium biforme DSM 3989
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -8.138; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Bacteroides pectinophilus ATCC 43243
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -7.783; p = 0.013). | |||
|
Studied Microbe: Blautia hansenii DSM20583
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Blautia hansenii DSM20583 (log2FC = -6.823; p = 0.036). | |||
|
Studied Microbe: Blautia luti DSM 14534
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Blautia luti DSM 14534 (log2FC = -6.367; p = 0.005). | |||
|
Studied Microbe: Bryantia formatexigens DSM 14469
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -7.41; p = 0.006). | |||
|
Studied Microbe: Clostridium asparagiforme DSM 15981
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -7.968; p = 0.004). | |||
|
Studied Microbe: Clostridium difficile 120
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Clostridium difficile 120 (log2FC = -7.314; p = 0.005). | |||
|
Studied Microbe: Clostridium hathewayi DSM 13479
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -6.841; p = 0.016). | |||
|
Studied Microbe: Clostridium scindens ATCC 35704
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -6.708; p = 0.021). | |||
|
Studied Microbe: Clostridium sp.
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Clostridium sp. (log2FC = -6.724; p = 0.026). | |||
|
Studied Microbe: Clostridium sporogenes ATCC 15579
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -7.291; p = 0.008). | |||
|
Studied Microbe: Coprococcus comes ATCC 27758
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -7.32; p = 0.006). | |||
|
Studied Microbe: Dorea formicigenerans ATCC 27755
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -6.84; p = 0.003). | |||
|
Studied Microbe: Eubacterium hallii DSM3353
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Eubacterium hallii DSM3353 (log2FC = -8.227; p = 0.014). | |||
|
Studied Microbe: Eubacterium rectale ATCC 33656
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -6.46; p = 0.012). | |||
|
Studied Microbe: Eubacterium ventriosum ATCC 27560
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -4.364; p = 0.003). | |||
|
Studied Microbe: Roseburia intestinalis L1-82
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Roseburia intestinalis L1-82 (log2FC = -7.126; p = 0.003). | |||
|
Studied Microbe: Ruminococcus gnavus ATCC 29149
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -5.867; p = 0.022). | |||
|
Studied Microbe: Ruminococcus torques ATCC 27756
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -8.429; p = 0.019). | |||
|
Studied Microbe: Subdoligranulum variabile DSM 15176
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -6.636; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
|
Studied Microbe: Enterococcus faecalis V583
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Enterococcus faecalis V583 (log2FC = -6.178; p = 0.003). | |||
|
Studied Microbe: Lactobacillus reuteri CF48-3A
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -7.912; p = 0.026). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
|
Studied Microbe: Anaerococcus hydrogenalis DSM 7454
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -5.955; p = 0.041). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
|
Studied Microbe: Akkermansia muciniphila ATCC BAA-835
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -6.817; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
|
Studied Microbe: Victivallis vadensis ATCC BAA-548
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tenatoprazole can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -5.916; p = 0.01). | |||
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Blautia obeum
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Tenatoprazole (adjusted p-values: 3.49E-06). | |||
|
Studied Microbe: Dorea formicigenerans
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Tenatoprazole (adjusted p-values: 7.59E-04). | |||
|
Studied Microbe: Roseburia intestinalis
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Tenatoprazole (adjusted p-values: 1.49E-03). | |||
|
Studied Microbe: Ruminococcus torques
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Tenatoprazole (adjusted p-values: 3.91E-05). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gastric H(+)/K(+) ATPase (Proton pump) | Target Info | Modulator | [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00282555) Efficiency Study of S-Tenatoprazole-Na to Treat Erosive or Ulcerative Esophagitis. U.S. National Institutes of Health. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 4 | Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in heal... Aliment Pharmacol Ther. 2004 Mar 15;19(6):655-62. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.