Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N1EW
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Former ID |
DIB003843
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Drug Name |
DuP-532
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Synonyms |
Dup-532; Dup 532; 124750-95-4; CHEMBL443269; 1H-Imidazole-5-carboxylicacid,4-(1,1,2,2,2-pentafluoroethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-; dup532; ACMC-20mr6i; SCHEMBL62; AC1L1TVZ; AC1Q4ICA; CTK4B4065; BDBM82428; DTXSID00154476; PDSP2_000123; PDSP1_000124; PDSP1_000123; BDBM50230908; 2-Propyl-4-pentafluoroethyl-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)imidazole-5-carboxylic acid; CAS_124750-95-4; CB91356279; L002873; 1H-Imidazole-5-carboxylic acid, 4-(pentafluoroethyl)-2-propyl-1-((2'-(1H-te
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Discontinued in Phase 1 | [1] | |
Company |
Bristol-Myers Squibb Pharma Co
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Structure |
Download2D MOL |
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Formula |
C23H19F5N6O2
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Canonical SMILES |
CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)C(C(F)(F)F)(F)F
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InChI |
1S/C23H19F5N6O2/c1-2-5-17-29-19(22(24,25)23(26,27)28)18(21(35)36)34(17)12-13-8-10-14(11-9-13)15-6-3-4-7-16(15)20-30-32-33-31-20/h3-4,6-11H,2,5,12H2,1H3,(H,35,36)(H,30,31,32,33)
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InChIKey |
RQGDXPDTZWGCQI-UHFFFAOYSA-N
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CAS Number |
CAS 124750-95-4
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Angiotensin II receptor (AGTR) | Target Info | Modulator | [2] |
KEGG Pathway | Calcium signaling pathway | |||
cGMP-PKG signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Adrenergic signaling in cardiomyocytes | ||||
Vascular smooth muscle contraction | ||||
Renin-angiotensin system | ||||
Renin secretion | ||||
Pathways in cancer |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001160) | |||
REF 2 | DuP 532, an angiotensin II receptor antagonist: first administration and comparison with losartan. Clin Pharmacol Ther. 1997 Jan;61(1):59-69. |
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