Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0MS3D
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| Former ID |
DIB019714
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| Drug Name |
Delta12-PGJ2
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| Synonyms |
Dddd-PGD2; delta(12)-PGJ2; delta-12-prostaglandin D2
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C20H30O4
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| Canonical SMILES |
CCCCCC(CC=C1C(C=CC1=O)CC=CCCCC(=O)O)O
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| InChI |
1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/b7-4-,18-14+/t16-,17-/m0/s1
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| InChIKey |
TUXFWOHFPFBNEJ-GJGHEGAFSA-N
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| CAS Number |
CAS 87893-54-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8242, 4265964, 7979702, 8616424, 14717669, 14924517, 26754836, 26754837, 39289874, 47290909, 48334229, 50065349, 50110797, 57357910, 74919478, 85788020, 92309700, 99300614, 99302132, 103640340, 104046455, 113854167, 126525046, 135069677, 135081387, 135651467, 139340649, 179151368, 184568146, 229391737, 241151930, 252455424, 252467260, 252819674
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| ChEBI ID |
CHEBI:28130
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin D2 receptor (PTGDR) | Target Info | Agonist | [2] |
| Prostaglandin D2 receptor 2 (PTGDR2) | Target Info | Agonist | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Pathwhiz Pathway | Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 | |||
| Pathway Interaction Database | Thromboxane A2 receptor signaling | |||
| Reactome | Prostanoid ligand receptors | |||
| G alpha (i) signalling events | ||||
| G alpha (s) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Prostaglandin Synthesis and Regulation | ||||
| Small Ligand GPCRs | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1876). | |||
| REF 2 | Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. | |||
| REF 3 | Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. | |||
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