Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0MR4Q
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| Former ID |
DIB000458
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| Drug Name |
Avacopan
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| Synonyms |
CCX-168
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| Indication | Anca-associated vasculitis [ICD-11: 4A44.A] | Approved | [1] | |
| Eosinophilic granulomatosis with polyangiitis [ICD-11: 4A44.A2; ICD-10: M30.1] | Phase 2 | [2] | ||
| Hereditary haemolytic anemia [ICD-11: 3A10.3; ICD-10: D58.8] | Phase 2 | [2] | ||
| Company |
ChemoCentryx
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| Structure |
 |
Download2D MOL |
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| Formula |
C33H35F4N3O2
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| Canonical SMILES |
CC1=C(C(=CC=C1)F)C(=O)N2CCCC(C2C3=CC=C(C=C3)NC4CCCC4)C(=O)NC5=CC(=C(C=C5)C)C(F)(F)F
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| InChI |
1S/C33H35F4N3O2/c1-20-12-15-25(19-27(20)33(35,36)37)39-31(41)26-10-6-18-40(32(42)29-21(2)7-5-11-28(29)34)30(26)22-13-16-24(17-14-22)38-23-8-3-4-9-23/h5,7,11-17,19,23,26,30,38H,3-4,6,8-10,18H2,1-2H3,(H,39,41)/t26-,30-/m0/s1
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| InChIKey |
PUKBOVABABRILL-YZNIXAGQSA-N
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| CAS Number |
CAS 1346623-17-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | C5a anaphylatoxin chemotactic receptor (C5AR1) | Target Info | Antagonist | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Complement and coagulation cascades | ||||
| Staphylococcus aureus infection | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| Human Complement System | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2021. Application Number: 214487. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Clinical pipeline report, company report or official report of ChemoCentryx. | |||
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