Drug Information
Drug General Information | Top | |||
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Drug ID |
D0MI1N
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Former ID |
DIB005238
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Drug Name |
CR-5259
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Synonyms |
CR-4144 series; CR-4152 series; CR-4153 series; CR-4167 series; Aggrecanase (ADAMTS-4 and 5) inhibitors (osteoarthritis),Rottapharm Madaus
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Indication | Osteoarthritis [ICD-11: FA00-FA05; ICD-9: 715] | Investigative | [1] | |
Company |
Rottapharm Madaus
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Target and Pathway | Top | |||
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Target(s) | Aggrecanase (ADAMTS5) | Target Info | Inhibitor | [1] |
Reactome | Degradation of the extracellular matrix | |||
O-glycosylation of TSR domain-containing proteins | ||||
WikiPathways | Endochondral Ossification | |||
Vitamin D Receptor Pathway |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1677). |
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