Drug Information
Drug General Information | Top | |||
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Drug ID |
D0MH1X
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Former ID |
DIB018931
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Drug Name |
AZD1332
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Synonyms |
AZD 1332; AZD-1332
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C17H19ClFN7O
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Canonical SMILES |
CC(C)OC1=NNC(=C1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=C3)F
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InChI |
1S/C17H19ClFN7O/c1-9(2)27-15-6-14(25-26-15)23-16-12(18)8-21-17(24-16)22-10(3)13-5-4-11(19)7-20-13/h4-10H,1-3H3,(H3,21,22,23,24,25,26)
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InChIKey |
LBVKEEFIPBQIMD-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | BDNF/NT-3 growth factors receptor (TrkB) | Target Info | Inhibitor | [2] |
NT-3 growth factor receptor (TrkC) | Target Info | Inhibitor | [3] | |
KEGG Pathway | MAPK signaling pathway | |||
Neurotrophin signaling pathway | ||||
Alcoholism | ||||
Pathway Interaction Database | SHP2 signaling | |||
Posttranslational regulation of adherens junction stability and dissassembly | ||||
Neurotrophic factor-mediated Trk receptor signaling | ||||
Reactome | ARMS-mediated activation | |||
NGF-independant TRKA activation | ||||
PI3K/AKT activation | ||||
WikiPathways | MAPK Signaling Pathway | |||
BDNF signaling pathway | ||||
Integrated Pancreatic Cancer Pathway | ||||
NGF signalling via TRKA from the plasma membrane | ||||
SIDS Susceptibility Pathways |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7700). | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818). | |||
REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1817). |
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