Drug Information
Drug General Information | Top | |||
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Drug ID |
D0M7VY
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Former ID |
DNC010230
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Drug Name |
NSC-745796
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Synonyms |
NSC-745796; CHEMBL603842; SCHEMBL12261364; 2-phenyl-anthra[1,2-d]imidazole-6,11-dione
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C21H12N2O2
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Canonical SMILES |
C1=CC=C(C=C1)C2=NC3=C(N2)C=CC4=C3C(=O)C5=CC=CC=C5C4=O
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InChI |
1S/C21H12N2O2/c24-19-13-8-4-5-9-14(13)20(25)17-15(19)10-11-16-18(17)23-21(22-16)12-6-2-1-3-7-12/h1-11H,(H,22,23)
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InChIKey |
DONDWNNDTIOAET-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | TERT messenger RNA (TERT mRNA) | Target Info | Inhibitor | [1] |
KEGG Pathway | HTLV-I infection | |||
NetPath Pathway | IL2 Signaling Pathway | |||
Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
Regulation of Telomerase | ||||
IL2 signaling events mediated by PI3K | ||||
Regulation of nuclear beta catenin signaling and target gene transcription | ||||
HIF-1-alpha transcription factor network | ||||
Reactome | Formation of the beta-catenin:TCF transactivating complex | |||
WikiPathways | TGF beta Signaling Pathway | |||
miR-targeted genes in lymphocytes - TarBase | ||||
miR-targeted genes in epithelium - TarBase | ||||
Telomere Maintenance |
References | Top | |||
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REF 1 | Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. |
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