Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M7NA
|
|||
| Former ID |
DCL000026
|
|||
| Drug Name |
A-993610
|
|||
| Indication | Pain [ICD-11: MG30-MG3Z] | Investigative | [1] | |
| Therapeutic Class |
Analgesics
|
|||
| Company |
Abbott
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C19H17ClF3N3O
|
|||
| Canonical SMILES |
CC1CN(CC=C1C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=C(C=CC=N3)Cl
|
|||
| InChI |
1S/C19H17ClF3N3O/c1-12-11-26(17-16(20)3-2-9-24-17)10-8-15(12)18(27)25-14-6-4-13(5-7-14)19(21,22)23/h2-9,12H,10-11H2,1H3,(H,25,27)/t12-/m1/s1
|
|||
| InChIKey |
IYXRQYVHUISAIP-GFCCVEGCSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Blocker | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | TRPV1 receptor blockade is ineffective in different in vivo models of migraine. Cephalalgia. 2011 Jan;31(2):172-80. | |||
| REF 2 | Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.