Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M0YH
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| Former ID |
DIB019864
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| Drug Name |
fMet-Leu-Phe
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| Synonyms |
fMetLeuPhe; formyl-Met-Leu-Phe
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL
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| Formula |
C21H31N3O5S
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| Canonical SMILES |
CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
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| InChI |
1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
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| InChIKey |
PRQROPMIIGLWRP-BZSNNMDCSA-N
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| CAS Number |
CAS 59880-97-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13761, 7979309, 10299271, 15255880, 24871354, 24894846, 36886639, 50076428, 53788451, 56323719, 57404334, 57651094, 76715943, 81067114, 87246508, 91697294, 93576761, 103165446, 103948030, 104629627, 124801087, 127320376, 127320377, 128958529, 134344725, 135652157, 135697809, 137019908, 140715047, 144224142, 160654666, 162220825, 164756522, 179316750, 184562936, 226424894, 241375691, 252156187, 252360975
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| ChEBI ID |
CHEBI:53490
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | FMLP-related receptor I (FPR2) | Target Info | Agonist | [1] |
| N-formyl peptide receptor (FPR1) | Target Info | Agonist | [2] | |
| KEGG Pathway | Rap1 signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Staphylococcus aureus infection | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
| Reactome | G alpha (q) signalling events | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Human Complement System | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. J Biol Chem. 1993 Aug 25;268(24):18167-75. | |||
| REF 2 | Further studies on the structural requirements for synthetic peptide chemoattractants. Biochemistry. 1980 May 27;19(11):2404-10. | |||
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