Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0LR1M
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| Former ID |
DIB003495
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| Drug Name |
LY-444711
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| Synonyms |
2(R)-(2-Amino-2-methylpropanamido)-N-[1-[1(R)-(4-methoxyphenyl)-1-methyl-2-oxo-2-(1-pyrrolidinyl)ethyl]-1H-imidazol-4-yl]-5-phenylpentanamide dihydrochloride
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| Indication | Growth hormone deficiency [ICD-11: 5A61.3] | Discontinued in Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C32H42N6O4
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| Canonical SMILES |
CC(C)(C(=O)NC(CCCC1=CC=CC=C1)C(=O)NC2=CN(C=N2)C(C)(C3=CC=C(C=C3)OC)C(=O)N4CCCC4)N
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| InChI |
1S/C32H42N6O4/c1-31(2,33)29(40)35-26(14-10-13-23-11-6-5-7-12-23)28(39)36-27-21-38(22-34-27)32(3,30(41)37-19-8-9-20-37)24-15-17-25(42-4)18-16-24/h5-7,11-12,15-18,21-22,26H,8-10,13-14,19-20,33H2,1-4H3,(H,35,40)(H,36,39)/t26-,32-/m1/s1
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| InChIKey |
MJUQKUGRKDKGBY-HVIPQOSHSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Growth hormone secretagogue receptor 1 (GHSR) | Target Info | Agonist | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012573) | |||
| REF 2 | Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5873-6. | |||
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