Drug Information
Drug General Information | Top | |||
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Drug ID |
D0LL1F
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Former ID |
DNC011264
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Drug Name |
[2-Phenylacetophenone]thiosemicarbazone
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Synonyms |
CHEMBL1269810; [2-Phenylacetophenone]thiosemicarbazone
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C15H15N3S
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Canonical SMILES |
C1=CC=C(C=C1)CC(=NNC(=S)N)C2=CC=CC=C2
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InChI |
1S/C15H15N3S/c16-15(19)18-17-14(13-9-5-2-6-10-13)11-12-7-3-1-4-8-12/h1-10H,11H2,(H3,16,18,19)/b17-14+
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InChIKey |
WHRFFXUXTGIZOH-SAPNQHFASA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Cathepsin L (CTSL) | Target Info | Inhibitor | [1] |
KEGG Pathway | Lysosome | |||
Phagosome | ||||
Antigen processing and presentation | ||||
Proteoglycans in cancer | ||||
Rheumatoid arthritis | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
Reactome | Endosomal/Vacuolar pathway | |||
Collagen degradation | ||||
Degradation of the extracellular matrix | ||||
Trafficking and processing of endosomal TLR | ||||
Assembly of collagen fibrils and other multimeric structures | ||||
MHC class II antigen presentation | ||||
WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS |
References | Top | |||
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REF 1 | Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. |
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