Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0LI5N
|
|||
| Drug Name |
IONIS-PTP1BRX
|
|||
| Indication | Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] | Phase 2 | [1] | |
| Company |
onis Pharmaceuticals Carlsbad, CA
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein-tyrosine phosphatase 1B (PTP1B) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Adherens junction | |||
| Insulin signaling pathway | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Panther Pathway | Cadherin signaling pathway | |||
| Pathway Interaction Database | Insulin Pathway | |||
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | ||||
| Signaling events mediated by PTP1B | ||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||||
| Signaling events mediated by TCPTP | ||||
| IGF1 pathway | ||||
| EGF receptor (ErbB1) signaling pathway | ||||
| Posttranslational regulation of adherens junction stability and dissassembly | ||||
| PDGFR-beta signaling pathway | ||||
| N-cadherin signaling events | ||||
| Reactome | Integrin alphaIIb beta3 signaling | |||
| Regulation of IFNG signaling | ||||
| Regulation of IFNA signaling | ||||
| Growth hormone receptor signaling | ||||
| WikiPathways | Insulin Signaling | |||
| Growth hormone receptor signaling | ||||
| Leptin signaling pathway | ||||
| Interferon gamma signaling | ||||
| Interferon alpha/beta signaling | ||||
| Integrin alphaIIb beta3 signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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