Drug Information
Drug General Information | Top | |||
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Drug ID |
D0LC5O
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Former ID |
DIB018099
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Drug Name |
(S)-3,4-DCPG
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Synonyms |
(S)-3,4-dicarboxylphenylglycine
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C10H9NO6
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Canonical SMILES |
C1=CC(=C(C=C1C(C(=O)O)N)C(=O)O)C(=O)O
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InChI |
1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
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InChIKey |
IJVMOGKBEVRBPP-ZETCQYMHSA-N
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CAS Number |
CAS 201730-11-2
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Metabotropic glutamate receptor 4 (mGluR4) | Target Info | Agonist | [2] |
Metabotropic glutamate receptor 6 (mGluR6) | Target Info | Agonist | [2] | |
Metabotropic glutamate receptor 8 (mGluR8) | Target Info | Agonist | [2] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Glutamatergic synapse | ||||
Taste transduction | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Metabotropic glutamate receptor group III pathway | ||||
Reactome | G alpha (i) signalling events | |||
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1407). | |||
REF 2 | (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8. |
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