Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L9BG
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| Drug Name |
PMID29473428-Compound-10
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| Drug Type |
Small molecular drug
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| Company |
IOMET PHARMA LTD. MERCK SHARP & DOHME CORP. COWLEY, Phillip, M. WISE, Alan BROWN, Thomas, J. MCGOWAN, Meredeth, A. ZHOU, Hua HAN, Yongxin
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H19BrN4O2S
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| Canonical SMILES |
CC1(CN(CCN1S(=O)(=O)C)C2=CC(=CC3=CN=CN23)Br)C
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| InChI |
1S/C14H19BrN4O2S/c1-14(2)9-17(4-5-19(14)22(3,20)21)13-7-11(15)6-12-8-16-10-18(12)13/h6-8,10H,4-5,9H2,1-3H3
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| InChIKey |
MJEJSWKBPXDOCH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target Info | . | [1] |
| Target's Patent Info | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target's Patent Info | [1] | |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation | ||||
| L-kynurenine degradation | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| NAD de novo biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| African trypanosomiasis | ||||
| NetPath Pathway | TSLP Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| Reactome | Tryptophan catabolism | |||
| WikiPathways | Tryptophan metabolism | |||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. | |||
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