Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L8MO
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| Former ID |
DIB003461
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| Drug Name |
ME-3407
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| Synonyms |
EF-4040; 2-(Butoxycarbonylmethylsulfinyl)thiazolo[5,4-b]pyridine; 2-(Thiazolo[5,4-b]pyridin-2-ylsulfinyl)acetic acid butyl ester
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| Drug Type |
Small molecular drug
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| Indication | Duodenal ulcer [ICD-11: DA63] | Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H14N2O3S2
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| Canonical SMILES |
CCCCOC(=O)CS(=O)C1=NC2=C(S1)N=CC=C2
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| InChI |
1S/C12H14N2O3S2/c1-2-3-7-17-10(15)8-19(16)12-14-9-5-4-6-13-11(9)18-12/h4-6H,2-3,7-8H2,1H3
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| InChIKey |
BUXNKFNNJJTLOS-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Myosin light kinase (MYLK) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Vascular smooth muscle contraction | ||||
| Focal adhesion | ||||
| Platelet activation | ||||
| Regulation of actin cytoskeleton | ||||
| Oxytocin signaling pathway | ||||
| Gastric acid secretion | ||||
| Panther Pathway | Cytoskeletal regulation by Rho GTPase | |||
| Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin | |||
| Muscle/Heart Contraction | ||||
| Pathway Interaction Database | Aurora B signaling | |||
| Reactome | Smooth Muscle Contraction | |||
| WikiPathways | Regulation of Actin Cytoskeleton | |||
| Focal Adhesion | ||||
| Endothelin Pathways | ||||
| Muscle contraction | ||||
| MicroRNAs in cardiomyocyte hypertrophy | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H(+)-K(+)-ATPase. Am J Physiol. 1997 May;272(5 Pt 1):G1122-34. | |||
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