Drug Information
Drug General Information | Top | |||
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Drug ID |
D0L4RX
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Former ID |
DNC012880
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Drug Name |
PB-81
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Synonyms |
PB-81
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C26H31N7O3S
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Canonical SMILES |
CC(C)(C)NC(=O)CN(C1CC2=C(C=CC(=C2)C#N)N(C1)CC3=CN=CN3C)S(=O)(=O)C4=CC=NC=C4
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InChI |
1S/C26H31N7O3S/c1-26(2,3)30-25(34)17-33(37(35,36)23-7-9-28-10-8-23)21-12-20-11-19(13-27)5-6-24(20)32(15-21)16-22-14-29-18-31(22)4/h5-11,14,18,21H,12,15-17H2,1-4H3,(H,30,34)
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InChIKey |
VXYRLLDULVRHBY-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | CAAX farnesyltransferase beta (FNTB) | Target Info | Inhibitor | [1] |
Farnesyl protein transferase (Ftase) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Terpenoid backbone biosynthesis | |||
Biosynthesis of antibiotics | ||||
NetPath Pathway | TSH Signaling Pathway | |||
Reactome | Inactivation, recovery and regulation of the phototransduction cascade | |||
WikiPathways | Visual phototransduction |
References | Top | |||
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REF 1 | Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. |
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