Drug Information
Drug General Information | Top | |||
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Drug ID |
D0L4HY
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Former ID |
DAP000232
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Drug Name |
Guanabenz
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Synonyms |
GBZ; Guanabenzo; Guanabenzum; Wytensin; Guanabenz acetate; Guanabenz monoacetate; Wy 8678; Wy 8678 base; BR-750; Guanabenz [USAN:INN]; Guanabenz(USAN); Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; Wy-8678; Wytensin (TN); Guanabenz (USAN/INN); [(2,6-Dichlorobenzylidene)amino]guanidine; N-((2,6-Dichlorobenzylidene)amino)guanidine; Guanidine, ((2,6-dichlorobenzylidene)amino)-(8CI); N-(2,6-Dichlorobenzylidene)-N'-amidinohydrazine; ((2,6-Dichlorobenzylidene)amino)guanidine; 2,6-Dichlorobenzylideneaminoguanidine;2-((2,6-Dichlorophenyl)methylene)-hydrazinecarboximidamide; 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
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Drug Type |
Small molecular drug
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Indication | High blood pressure [ICD-11: BA00; ICD-10: I10; ICD-9: 401] | Approved | [1], [2] | |
Therapeutic Class |
Sympatholytics
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Company |
Eon Labs Manufacturing
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Structure |
Download2D MOL |
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Formula |
C8H8Cl2N4
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Canonical SMILES |
C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
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InChI |
1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+
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InChIKey |
WDZVGELJXXEGPV-YIXHJXPBSA-N
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CAS Number |
CAS 60329-03-5
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PubChem Compound ID | ||||
PubChem Substance ID |
9246, 113005, 15390940, 17434456, 24607029, 26665151, 26751943, 47206274, 47795034, 48018892, 48169358, 48243349, 48318400, 49698340, 50064822, 50070697, 50104618, 50104619, 57364886, 78424678, 81642163, 85209545, 85787575, 88878415, 90341577, 92098556, 92308809, 103164806, 103826246, 103936653, 114069183, 117464955, 124749846, 124886953, 126876159, 131342553, 131342557, 134337546, 134984370, 137010571, 137144691, 137149965, 139524299, 145257345, 160963974, 164037969, 164819317, 175266630, 176483965, 179038222
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ChEBI ID |
CHEBI:5553
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ADReCS Drug ID | BADD_D01044 |
Target and Pathway | Top | |||
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Target(s) | Adrenergic receptor Alpha-2 (ADRA2) | Target Info | Agonist | [3] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5443). | |||
REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074149. | |||
REF 3 | Centrally acting sympathetic inhibitors for therapy of patients with hypertension. Nippon Rinsho. 1997 Aug;55(8):2081-5. |
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