Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L2ZY
|
|||
| Former ID |
DNCL002239
|
|||
| Drug Name |
X-82
|
|||
| Indication | Age-related macular degeneration [ICD-11: 9B75.0; ICD-10: H35] | Phase 2 | [1] | |
| Macular degeneration [ICD-11: 9B78.3; ICD-10: H35.3] | Phase 1 | [2] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z] | Phase 1 | [2] | ||
| Company |
Tyrogenex West Palm Beach
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Platelet-derived growth factor receptor (PDGFR) | Target Info | Modulator | [3] |
| Vascular endothelial growth factor receptor (VEGFR) | Target Info | Inhibitor | [4] | |
| Vascular endothelial growth factor receptor 1 (FLT-1) | Target Info | Modulator | [3] | |
| KEGG Pathway | Ras signaling pathway | |||
| Rap1 signaling pathway | ||||
| Cytokine-cytokine receptor interaction | ||||
| HIF-1 signaling pathway | ||||
| Endocytosis | ||||
| PI3K-Akt signaling pathway | ||||
| Focal adhesion | ||||
| Transcriptional misregulation in cancer | ||||
| Rheumatoid arthritis | ||||
| Pathway Interaction Database | Glypican 1 network | |||
| HIF-2-alpha transcription factor network | ||||
| S1P3 pathway | ||||
| VEGF and VEGFR signaling network | ||||
| VEGFR1 specific signals | ||||
| Signaling events mediated by VEGFR1 and VEGFR2 | ||||
| Reactome | Neurophilin interactions with VEGF and VEGFR | |||
| VEGF binds to VEGFR leading to receptor dimerization | ||||
| WikiPathways | Focal Adhesion | |||
| Signaling by VEGF | ||||
| Angiogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02348359) X-82 to Treat Age-related Macular Degeneration. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of Tyrogenex. | |||
| REF 3 | National Cancer Institute Drug Dictionary (drug id 695817). | |||
| REF 4 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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