Drug Information
Drug General Information | Top | |||
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Drug ID |
D0L1UK
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Former ID |
DNC000148
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Drug Name |
Acid-activated omeprazole
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Synonyms |
Hydroxyfasudil; HYDROXYFASUDIL; 105628-72-6; Hydroxy-Fasudil; 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine; HA 1100; HA-1100; 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE; CHEMBL1233300; Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine; 5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one; HYDROXYFASUDIL;5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one; 1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-; HFS; 2etk; 2erz; AC1MI8J4; SCHEMBL123699
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C14H17N3O3S
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Canonical SMILES |
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O
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InChI |
1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)
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InChIKey |
ZAVGJDAFCZAWSZ-UHFFFAOYSA-N
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CAS Number |
CAS 105628-72-6
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PubChem Compound ID | ||||
PubChem Substance ID |
8028483, 8142703, 10062426, 14898703, 26755032, 29216379, 36398431, 46394055, 46394057, 46508609, 46514396, 48318734, 49961266, 57354139, 80688326, 104249468, 111650847, 118050706, 121278723, 125658888, 126660180, 129876018, 134224807, 134339663, 134340095, 135138692, 137008564, 137183652, 139403950, 143382892, 152040678, 160967691, 163366710, 172657822, 177748411, 179236068, 184596704, 201503199, 210275006, 210280644, 223573585, 226494738, 242281871, 252475194
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References | Top | |||
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REF 1 | ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole. Am J Physiol Cell Physiol. 2001 Jul;281(1):C46-54. | |||
REF 2 | Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice. Circ Res. 2004 Jan 9;94(1):46-52. |
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